PULMONARY EMBOLISM AND THE ROLE OF THE BLOOD CLOTTING SYSTEM IN ACUTE CALCULOUS CHOLECYSTITIS ON THE BACKGROUND OF OBESITY
Аннотация
Objective:The authors found a significant increase in the total coagulating activity of blood, an increase in the concentration of fibrinogen and proconvertin, and an increase in the number of platelets in patients with acute calculous cholecystitis (OCC) on the background of obesity. Methods:At the same time, the functional activity of the blood anticoagulation system is significantly reduced - the concentration of free heparin and fibrinolytic activity are reduced. Results:When performing the HE operation, the general clotting activity of the blood according to 2 tests (recalcification time, plasma tolerance to heparin) increases. In the postoperative period, changes in the coagulogram are reduced to a further significant increase in blood fibrinogen, an increase in plasma tolerance to heparin and a decrease in anticoagulant and fibrinolytic activity of the blood. Conclusions. A decrease in anticoagulant and fibrinolytic activity of the blood, an increase in the amount of fibrinogen, and plasma tolerance to heparin is essential in the mechanism of postoperative intravascular thrombosis.