UZBEKISTAN Itenko-Cushing

Cushing's disease is considered a rare disease characterized by hypersecretion of adrenocorticotropic hormone (ACTH) due to pituitary adenoma, which ultimately leads to endogenous hypercorticism by stimulating the adrenal glands. Clinical signs indicating Cushing's disease, such as obesity, moon face, hirsutism and an abundance of faces, are already present in the presentation. Endogenous hypercorticism is associated with cardiovascular and metabolic manifestations, as well as with an increased risk of respiratory diseases, mental complications, osteoporosis and infections, which leads to high levels of morbidity and mortality. It is very important to diagnose Cushing's disease as early as possible and implement a treatment plan that can lead to a successful prognosis and a small number of complications. The purpose of this article was to review the clinical, diagnostic and therapeutic aspects of Cushing's disease using the latest available guidelines.

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