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Early detection of lesions and maintenance of the normal functioning of the retinal tissue at an early stage of Non-Proliferative Diabetic Retinopathy (NPDR) is considered an extremely important step in its secondary prevention, which makes it advisable to include angio protective drugs in the complex of conservative therapy.One of the drugs of interest is "Doxy-Chem" -(calcium dobesilate) a drug that improves retinal microcirculation, is able to prevent and correct biochemical changes in nerve tissues, and has an endothelio protective effect.The aim of the study was to evaluate the effectiveness of the use of the drug "Doxy-chem" in patients with an early stage of NPDR.Analysis of the results showed that in the group of patients who received "Doxychem" there was an improvement in visual acuity by an average of 0.20±0.02(p<0.05), a decrease in the thickness of the retina (CTS) by an average of 1.60 micron (p<0.05), as well as a decrease in the thickness of the retina in other parts of the central zone in 75% of cases (44 eyes).While in the control group, the studied functional and Doppler indicators did not change significantly (p>0.05).The present study showed that therapy with Doxychem improves ocular blood flow in the retrobulbar vessels, especially in the central retinal artery and the short posterior ciliary artery.

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