Обзорная статья

The role of miRNA-128 in the development and progression of gastrointestinal and urogenital cancer

Ghaidaa Raheem Lateef Al‐AwsiDepartment of Radiological Techniques,Al-Mustaqbal University College, Babylon, IraqSaade Abdalkareem JasimDepartment of Medical Laboratory Techniques,Al-maarif University College, Al-Anbar-Ramadi, IraqYasser Fakri MustafaDepartment of Pharmaceutical Chemistry,College of Pharmacy,University of Mosul, Mosul, 41001, IraqFiras Rahi AlhachamiDepartment of Radiology,College of Health & Medical Technololgy,Al-Ayen University, Thi-Qar, IraqShukhrat ZiyadullaevNo. 1 Department of Internal Diseases, Vice-rector for Scientific Affairs & Innovations,Samarkand State Medical University, Amir Temur Street 18, Samarkand, UzbekistanMahmoud KandeelDepartment of Biomedical Sciences,College of Veterinary Medicine,King Faisal University, Al-Hofuf, Al-Ahsa, 31982, Saudi ArabiaRoua AbulkassimAl-Manara College for Medical Science, Misan, IraqR. SivaramanDepartment of Mathematics,Dwaraka Doss Goverdhan Doss Vaishnav College, Arumbakkam,University of Madras, Chennai, IndiaNoora M. HameedAnesthesia Techniques,Al-Nisour University College, IraqRosario Mireya Romero‐ParraUniversidad Continental, Lima, PerúSajad KarampoorGastrointestinal & Liver Diseases Research Center,Iran University of Medical Sciences, Tehran, IranRasoul MirzaeiDepartment of Medical Biotechnology,Venom & Biotherapeutics Molecules Lab,Biotechnology Research Center,Pasteur Institute of Iran, Tehran, Iran

Future Oncologyjournal2022en

ABI

Аннотация

Increasing data have shown the significance of various miRNAs in malignancy. In this regard, parallel to its biological role in normal tissues, miRNA-128 (miR-128) has been found to play an essential immunomodulatory function in the process of cancer initiation and development. The occurrence of the aberrant expression of miR-128 in tumors and the unique properties of miRNAs raise the prospect of their use as biomarkers and the next generation of molecular anticancer therapies. The function of miR-128 in malignancies such as breast, prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian and bladder cancers and hepatocellular carcinoma is discussed in this review. Finally, the effect of exosomal miR-128 on cancer resistance to therapeutics and cancer immunotherapy in certain malignancies is highlighted.

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Темы

MicroRNA in disease regulation Circular RNAs in diseases Extracellular vesicles in disease

Идентификаторы

DOI: 10.2217/fon-2022-0574

Цитирования и источники

Цитирований: 0Использованных источников: 179

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