Обзорная статья

Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2

Chithravel VadivalaganGraduate Institute of Medical Sciences, College of medicine, Taipei Medical University, Taipei 110, Taiwan; Department of Biochemistry, AKFA Medical School, AKFA University, Tashkent, Uzbekistan. Electronic address: [email protected]Anushka ShitutDepartment of Life Sciences, Christ University, Bhavani, Nagar, Bangalor, Karnataka 560029, India. Electronic address: [email protected]Siva KamalakannanNational Center for Disease Control, Ministry of Health and Family Welfare, Government of India, New Delhi 110054, IndiaRuei‐Ming ChenGraduate Institute of Medical Sciences, College of medicine, Taipei Medical University, Taipei 110, TaiwanÁngel Serrano‐ArocaBiomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, Valencia, SpainVijay MishraSchool of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara, Punjab, IndiaAlaa A. A. AljabaliDepartment of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid 21163, JordanSachin Kumar SinghSchool of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara, Punjab, India; Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, AustraliaDinesh Kumar ChellappanSchool of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, MalaysiaGaurav GuptaSchool of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, IndiaKamal DuaSchool of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, AustraliaMohamed El‐TananiPharmacological and Diagnostic Research Centre, Al-Ahliyya Amman University, Faculty of Pharmacy, Amman, JordanMurtaza M. TambuwalaSchool of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, United Kingdom. Electronic address: [email protected]Anand KrishnanDepartment of Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South Africa; Department of Chemical Pathology, School of Pathology, National Health Laboratory Services, Bloemfontein, South Africa. Electronic address: [email protected]

Cellular Signallingjournal2022en

ABI

Аннотация

Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic positions, and single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation. Several vaccines were developed and in treatment practice, but effective control has yet to reach in cent presence. It was initially a narrow immune-modulating protein target. Controlling these diverse viral strains may inhibit their transuding mechanisms primarily to target RNA genes responsible for COVID19 transcription. Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription. This review discussed targeted viral transcription by delivering the artificial miRNA (amiRNA) mediated exosomes in the infected cells and significant resources of exosome and their efficacy.

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Темы

Extracellular vesicles in disease SARS-CoV-2 and COVID-19 Research RNA Interference and Gene Delivery

Идентификаторы

DOI: 10.1016/j.cellsig.2022.110334

Цитирования и источники

Цитирований: 1 Использованных источников: 112

Показатели — AkademScholar