Cytotoxic activity of Quinoline alkaloids and their derivatives
Zilola KabirovaDepartment of Molecular genetics, S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, 100170, Tashkent, Uzbekistan,Nargiz IskandarovaDepartment of Molecular genetics, S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, 100170, Tashkent, Uzbekistan,Ekaterina TerentievaDepartment of Molecular genetics, S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, 100170, Tashkent, Uzbekistan,Farkhod EshboevDepartment of Molecular genetics, S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, 100170, Tashkent, Uzbekistan,Shakhnoza S. AzimovaDepartment of Molecular genetics, S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, 100170, Tashkent, Uzbekistan,
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Аннотация
Quinoline alkaloids, important class of N-based heterocyclic aromatic compounds, have attracted tremendous attention from researchers worldwide, because of their wide-ranging biological activities and their varied applications. In the present work, the cytotoxic activities of dubamine and its 15 derivatives against HBL-100 and CCRF-СЕМ cancer cells and healthy blood mononuclear cells were studied. Among the tested dubamine derivatives, four compounds showed cytotoxic activity. The LD<sub>50</sub> values of the substances was determined.
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