Polymorphism endothelin-1 gene (Lys198Аsn) in airway remodeling and increased endothelial dysfunction in COPD

<b>Purpose:</b> To study the effect of endothelin-1 gene polymorphism(Lys198Аsn) on airway remodeling and vascular endothelial dysfunction in patients with COPD. <b>Materials and methods:</b> The study included 123 patients diagnosed with COPD, who were divided into 2 groups according to the presence of defects in the endothelin-1 gene: group 1 (n=52) with a heterozygous or mutational genotype and group 2 (n= 71) with a normal homozygous genotype. The levels of von Willebrand factor(VWF) as a marker of endothelial dysfunction were determined by ELISA, and spirometry with bronchodilator reversibility test (BRT) was also performed. <b>Results:</b> In the 1st group of patients, the average level of the VWF was 112.4±6.1%, in the 2nd group it was 79.4±4.1%. An increase in the VWF was found in 75% of patients in the 1st group, while in the 2nd group it was 59.2%. The results of the spirometry showed that in the 1st group, the variability of FEV1 after the BRT averaged 5.2±1.4%, while in the 2nd group it was 9.4±1.1%, which may indicate a greater resistance of the airways and be a sign of remodeling and more persistent obstruction. Conclusions: The predominance of an increase in VWF in the group of patients with a defect in the endothelin-1 gene (p&lt;0.01) and a higher proportion of patients with elevated levels of VWF indicates an increase in endothelial dysfunction in the presence of this polymorphism, while a decrease in FEV1 variability with the use of BRT may indicate a parallel effect of a defect in the gene on the deposition of collagen in the respiratory epithelium of the bronchi and the development of a more persistent obstruction.

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