Assessment of The Level of Neopterin in Oral Fluid and Blood Plasma in Patients with Rheumatoid Arthritis
Rakhimov Shokhrukh ShonazarovichAssistant of the Department of Dentistry of the Urgench branch of the Tashkent Medical AcademyIdiev Gayrat.ElmurodovichBukhara State Medical Institute named after Abu Ali ibn Sina Associate Professor of the Department of Orthopedic Dentistry and Orthodontics, Candidate of Medical Sciences (DSc)Ibragimova Firuza IkrоmovnaBukhara State Medical Institute named after Abu Ali ibn Sina 3 Associate Professor of the Department of Orthopedic Dentistry and Orthodontics, Candidate of Medical Science3
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Аннотация
It is known that neopterin is a metabolite of nucleic bases, similar in structure to a folic acid molecule (Lazarchik I.V. et al., 2016). It is synthesized mainly by cells of the macrophage-monocyte pool under the influence of gamma interferon and reflects the synthesis of this cytokine, which plays a significant role in the immune response (Domínguez-Pérez R.A. et al., 2017). It is the synthesis of gamma interferon that distinguishes most cytotoxic cellular immune reactions in the course of an antiviral or antitumor immune response (Patel B.P. et al., 2007). And also, in autoimmune diseases – and specific immune inflammation Dudina K.R. et al., 2017).
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