INNOVATIVE TECHNOLOGIES IN THE FIELD OF CREATING EFFECTIVE PLANTS FROM AVICENNA RECIPES

Abu Ali ibn Sina (980-1037) was born in the village of Afshana, Bukhara region in August 980.After studying medicine at Nuqs al-Qumri, at the age of 16-17, he became a renowned physician due to his keen mind and memory.Ibn Sina wrote 280 works, 40 of them were devoted to medicine.His works had a great influence on the development of medicine and pharmacy in the modern world.Ibn Sina's main work on medicine and pharmacy is the Canon of Medical Science, which was widely circulated in Europe for many centuries and was used as a textbook for future doctors.Ibn Sina was one of the first scientists to develop a systematic approach to the study of medicines and he described and classified plants.In the "Canon of Medicine" Ibn Sina gives characteristics of medicinal raw materials, methods of manufacturing medicines and their use in the idea of infusions, decoctions,raw extracts, pills, etc.He described the use of more than 500 medicinal plants, 176 ofthem grow in Uzbekistan.These plants belong to various families and genera, many of them have been used to treat a wide range of diseases.As a result of the work of the Institute of Chemistry of Plant Substances named after.acad.S.Yu.Yunusov isolated 1200 alkaloids, 500 flavonoids, coumarins, lactones and proanthocyanidins, 350 glycosides, 50 lipids, 30 polysaccharides from the flora of Central Asia.The chemical structures of 625 new alkaloids, 180 glycosides, 300flavonoids, coumarins, lactones and proanthocyanidins have been established.Pharmacological tests were carried out on 2000 natural and synthetic substances, 60 compounds underwent preclinical and clinical trials.35 drugs have been introducedinto medical practice.Currently, the Institute continues fundamental chemical and pharmaceutical research on secondary metabolites of medicinal plants included in the "Canon of Medicine" of Abu Ali ibn Sina, with the aim of creating new highly effective medicines based on them.Traditional technologies for the extraction and purification of biologically active substances (BAS) from medicinal plants have a number of disadvantages that do notallow the extraction of many BAS in their native form.These disadvantages are: long time and multi-stage process, the use of toxic and explosive extractants, large losses oftarget products and solvents.Therefore, traditional technologies are constantly beingimproved.In recent years, the technology for extracting non-polar and mid-polar biologically active substances using liquefied gases in subcritical and supercritical states (fluid extraction), which is a promising alternative to overcome the above-mentioned disadvantages, has become widespread.The advantages of supercritical fluids (CO2, refrigerant, freon, propane, etc.) include properties such as high diffusion, low viscosity, high selectivity and high dissolving ability.Among them, carbon dioxide (CO2) is considered the preferred extractant dueto its nontoxicity, inertness, low cost, non-flammability and non-corrosiveness.FluidCO2 extraction is

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