Другое

Front Cover: Furo[2,3‐<i>d</i>]pyrimidines as Mackinazolinone/Isaindigotone Analogs: Synthesis, Modification, Antitumor Activity, and Molecular Docking Study (Chem. Biodiversity 3/2023)

Buer SongState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences South Beijing Rd 40–1 Urumqi 830011 P. R. ChinaLifei NieState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences South Beijing Rd 40–1 Urumqi 830011 P. R. ChinaKhurshed BozorovFaculty of Chemistry Samarkand State University University Blvd. 15 Samarkand 140104 UzbekistanChao NiuState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences South Beijing Rd 40–1 Urumqi 830011 P. R. ChinaRustamkhon KuryazovFaculty of Chemistry Samarkand State University University Blvd. 15 Samarkand 140104 UzbekistanHaji Akber AisaState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences South Beijing Rd 40–1 Urumqi 830011 P. R. ChinaJiangyu ZhaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences South Beijing Rd 40–1 Urumqi 830011 P. R. China

Chemistry & Biodiversityjournal2023en

ABI

Аннотация

Front Cover. Cancer has become a leading cause of death worldwide, oncology suggests chemotherapeutical drugs based on synthesized anticancer agents, phytomedicine, and metal complexes so far. On this basis, naturally-occurring alkaloids mackinazolinone and isaindigotone were as templates of target heterocycles, the synthesis of tricyclofuran[2,3-d]pyrimidine was studied under scaffold-hopping strategies, the synthesized compounds showed inhibitory effects on human cervical cancer HeLa and colon HT-29 cells. The results of molecular docking showed that the compounds with antitumor activity were well bound to the target EGFR protein and the matching degree was high, so the compounds have potential prospect, as reported by B. Song et al. in their research article at 10.1002/cbdv.202201059. 2023 VOLUME 20 NO. 3

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Темы

Quinazolinone synthesis and applications Cancer therapeutics and mechanisms Mycobacterium research and diagnosis

Идентификаторы

DOI: 10.1002/cbdv.202300282

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Цитирований: 1Использованных источников: 0

Показатели — AkademScholar