INFLUENCE OF LEAD ACETATE ON LIPID PEROXIDATION IN THE PROCESS OF LIVER MITOCHONDRIAL MEMBRANE AND ITS CORRECTION WITH DHQ-11 CONJUGAT

Mitochondria placed in the cell are targets for heavy metals. Among them, Pb2+ ions have a negative impact on the functional system of mitochondria[4,5]. Under the influence of heavy metals, there is a violation of electron transport in the mitochondrial respiratory chain and an increase in the amount of ROS. Damage to the mitochondrial membrane caused by heavy metals can be repaired with plant substances. However, the effect of the DHQ-11 conjugate [3] based on the flavonoid dihydroquercetin separated from the Siberian cedar and the isoquinoline alkaloid F-18 on LPO induced by Pb2+, Fe2+ and ADP in the liver mitochondrial membrane has not been investigated in vitro [4].

Перевод пока недоступен