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Influence of Dynamics of Changes in the Physical Properties of Osteoconductive Granulated Biopolymers on Scafold Stability in the Postoperative Period

Oleg V. SlesarevDepartment of Maxillofacial Surgery and Dentistry, Samara State Medical University, 443099 Samara, Russian FederationDarya V. MalchikovaDepartment of Maxillofacial Surgery and Dentistry, Samara State Medical University, 443099 Samara, Russian FederationВ. И. ПлатоновDepartment of Chemistry, Samara National Research University, 443086 Samara, Russian FederationNatalia A. MaksimenkoResearch Institute of Biotechnology, Samara State Medical University, 443099 Samara, Russian FederationA. A. MelnikovDepartment of Metals Technology and Aviation Materials, Samara National Research University, 443086 Samara, Russian FederationMariya A. AnikinaDepartment of Chemistry, Samara National Research University, 443086 Samara, Russian FederationRavshanbek B. AbdullaevDepartment of faculty and hospital therapy, Urgench branch of the Tashkent Medical Academy, 100004 Urgench, Republic of Uzbekistan
Preprints.orgrepository2023en
ABI

Аннотация

Osteoconductive granulated biopolymers (OGB) are used to restore the lost volume of the jaw bone. OGB is employed as a loose fraction and exhibits physical traits common to bulk mixtures. By removing air bubbles and industrial dust from the OGB fraction through special processing, more accessible spaces are left over for the adsorption of bone growth factors. The recipient site's biological environment alters the OGB fraction's physical characteristics. This is the cause of the OGB fraction's volume changing uncontrollably during the first three weeks following surgery. Predictive indicators for describing the physical processes of osteoconduction include the compaction coefficient and adsorption capacity. Taking into account the prognostic indicators of the dynamics of changes in the physical properties of the OGB fraction in the postoperative period, 3D planning of the bioengineered structure should be done. The OGB fraction's adsorption and drainage properties are optimized by raising the purity of OGB production and preparing the biopolymer for clinical studies.

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