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Role and Recent Advancements of Ionic Liquids in Drug Delivery Systems

Monu Kumar ShuklaDepartment of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan 173229, IndiaHarshita TiwariDiscovery Informatics Lab, Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, IndiaRachna VermaDepartment of Basic Sciences, Shoolini University, Solan 173229, IndiaWen-Liang DongSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaShavkatjon AzizovDepartment of Pharmaceutical Chemistry, Tashkent Pharmaceutical Institute, Tashkent 100015, UzbekistanBrajesh KumarDepartment of Chemistry, TATA College, Kolhan University, Chaibasa 833202, IndiaSadanand PandeyDepartment of Chemistry, College of Natural Sciences, Yeungnam University, Gyeongsan 38541, Republic of KoreaDeepak KumarDepartment of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan 173229, India
Pharmaceuticsjournal2023en
ABI

Аннотация

Advancements in the fields of ionic liquids (ILs) broaden its applications not only in traditional use but also in different pharmaceutical and biomedical fields. Ionic liquids "Solutions for Your Success" have received a lot of interest from scientists due to a myriad of applications in the pharmaceutical industry for drug delivery systems as well as targeting different diseases. Solubility is a critical physicochemical property that determines the drug's fate at the target site. Many promising drug candidates fail in various phases of drug research due to poor solubility. In this context, ionic liquids are regarded as effective drug delivery systems for poorly soluble medicines. ILs are also able to combine different anions/cations with other cations/anions to produce salts that satisfy the concept behind the ILs. The important characteristics of ionic liquids are the modularity of their physicochemical properties depending on the application. The review highlights the recent advancement and further applications of ionic liquids to deliver drugs in the pharmaceutical and biomedical fields.

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