Impact of <i>Ascaris lumbricoides</i> infection on the development of chronic pulmonary aspergillosis in patients with COPD
Abdurakhim ToychievPostdoctoral Researcher, Department of Immunology of Parasitic and Fungal Diseases, Republican Specialized Research and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, UzbekistanNatalya GafnerPulmonologist, Department of Therapy, Republican Specialized Scientific and Practical Medical Center of Tuberculosis and Pulmonology, Tashkent, UzbekistanVera BelotserkovetsPulmonologist, Department of Therapy, Republican Specialized Scientific and Practical Medical Center of Tuberculosis and Pulmonology, Tashkent, UzbekistanDildora SeklerSenior Researcher, Department of Immunology of Parasitic and Fungal Diseases, Republican Specialized Research and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, UzbekistanShakhnoza TashpulatovaAssociate Professor, Department of Infectious and Child Infectious Diseases, Tashkent Medical Academy, Tashkent, UzbekistanSvetlana OsipovaPrincipal Investigator, Department of Immunology of Parasitic and Fungal Diseases, Republican Specialized Research and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan
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Аннотация
The aetiopathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear. The aim of our study was to determine the possible influence of Ascaris lumbricoides on the development of chronic pulmonary aspergillosis (CPA) in patients with COPD. The prevalence of A. lumbricoides in patients with COPD with CPA (19.05%) was significantly higher than that in those without (9.20%) and controls (4.9%) ( p < 0.05). Trends in levels of Interleukin-1β and of tumour necrosis factor α suggest ascariasis increases susceptibility to Aspergillus sp. in patients with COPD and can be considered an additional risk factor for CPA.
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Показатели — AkademScholar · Скоро