ASSOCIATION OF RS6817105 POLYMORPHISM OF THE PITX2 GENE WITH ATRIAL FIBRILLATION IN PATIENTS WITH ARTERIAL HYPERTENSION IN THE UZBEK POPULATION

Objective: Determine the influence of the rs6817105 polymorphism of the PITX2 gene on the risk of developing atrial fibrillation (AF) in patients with arterial hypertension (AH) in the Uzbek population. Design and method: Included 142 patients who were initially diagnosed with paroxysmal (n=15), persistent (n=43) and permanent (n=84) forms of AF. Control group (n=88) hypertensive patients without AF. Echocardiography evaluate the indexed left atrial volume (LAVI). Genotyping of samples for carriage of allelic variants rs6817105 by polymorphism of the PITX2 gene was carried out using the RFLP-PCR method. Relative risk (OR) was calculated using genetic models. Results: Patients with hypertension and AF,the following distribution of genotypes of rs6817105 polymorphism of the PITX2 gene was revealed: CC genotype -72(50.7%) patients, CT genotype-in 60 (42.3%), TT genotype-10(7.0%), χ 2 =68.535,p=0.000. The allelic distribution showed a predominance of carriage of the C allele:C allele–71.8%, T allele–28.2%, χ 2 =106.542, p=0.000. Patients with AH without AF,the C allele also prevailed:59.7% and 40.3%, respectively, χ 2 =12.375,p=0.000. Ratio of CC:ST:TT genotypes:38.6%:42.1%:19.3%, χ 2 =12.375, p=0.000. Multiplicative model of inheritance,a significant accumulation of the C allele was demonstrated among 142 patients AH with AF in 71.8% (χ 2 =7.30;p= 0.007;OR=1.72,95%CI 1.16-2.56),while the T allele was less common in 28.2% cases.General model demonstrated the association of the CC genotype with the risk of developing AF in patients with hypertension,CC genotype was more common in 50.7% (χ 2 =8.69;P=0.01;OR=1.63,95%CI 0.95-2.81), while CT genotype was found in 42.3% of cases and TT genotype in 7.0%.Group of patients without AF there was a different distribution of CC:CT:TT genotypes:38.6%:42.0%:19.3%,respectively.It is important to note that in hypertensive patients with AF-carriers of the CC genotype rs6817105 polymorphism of the PITX2 gene,the LAVI indicator was significantly higher in comparison with carriers of the CT and TT genotypes:46.8±14.9 ml/m2 versus 40.4±13.0 ml /m2 and 36.5±11.6 ml/m2, respectively(p=0.020). Conclusions: CC genotype and the C allele of the rs6817105 polymorphism of the PITX2 gene with the risk of developing AF in patients with hypertension in the Uzbek population. It was noted that in carriers of the CC genotype rs6817105 polymorphism of the PITX2 gene, the LAVI indicator was significantly higher in comparison with carriers of the CT and TT genotypes.

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