Обзорная статья

Targeting Hepatic Cancer Stem Cells (CSCs) and Related Drug Resistance by Small Interfering RNA (siRNA)

Saade Abdalkareem JasimMedical Laboratory Techniques Department, Al-maarif University College, Anbar, Iraq. [email protected]Omar Dheyauldeen SalahdinBiology Department, College of Education for pure science, University Of Anbar, Anbar, Iraq. [email protected]H. MalathiDepartment of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to be University, Bangalore, Karnataka, IndiaNeha SharmaSafia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi ArabiaZafar AminovDepartment of Public Health and Healthcare management, Samarkand State Medical University, 18 Amir Temur Street, Samarkand, UzbekistanAtreyi PramanikSchool of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, IndiaIsraa Hussein MohammedMohammed Abed JawadDepartment of Medical Laboratories Technology, Al-Nisour University College, Baghdad, IraqBenien C. GabelMedical laboratory technique college, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq

Cell Biochemistry and Biophysicsjournal2024en

ABI

Аннотация

Tumor recurrence after curative therapy and hepatocellular carcinoma (HCC) cells' resistance to conventional therapies is the reasons for the worse clinical results of HCC patients. A tiny population of cancer cells with a strong potential for self-renewal, differentiation, and tumorigenesis has been identified as cancer stem cells (CSCs). The discovery of CSC surface markers and the separation of CSC subpopulations from HCC cells have been made possible by recent developments in the study of hepatic (liver) CSCs. Hepatic CSC surface markers include epithelial cell adhesion molecules (EpCAM), CD133, CD90, CD13, CD44, OV-6, ALDH, and K19. CSCs have a significant influence on the development of cancer, invasiveness, self-renewal, metastasis, and drug resistance in HCC, and thus provide a therapeutic chance to treat HCC and avoid its recurrence. Therefore, it is essential to develop treatment approaches that specifically and effectively target hepatic stem cells. Given this, one potential treatment approach is to use particular small interfering RNA (siRNA) to target CSC, disrupting their behavior and microenvironment as well as changing their epigenetic state. The characteristics of CSCs in HCC are outlined in this study, along with new treatment approaches based on siRNA that may be used to target hepatic CSCs and overcome HCC resistance to traditional therapies.

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Темы

Cancer Cells and Metastasis MicroRNA in disease regulation RNA Interference and Gene Delivery

Идентификаторы

DOI: 10.1007/s12013-024-01423-5

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