Статья

Targeted Infection Control and Tissue Integration via pH-Sensitive Smart Coatings on Implant Surfaces

Marta Maria Alves PereiraDepartment of Dental Materials and Prosthodontics, School of DentistryRodolfo Debone PiazzaDepartment of Analytical Chemistry, Physical Chemistry and Inorganic, Institute of ChemistryPaula Aboud BarbugliDepartment of Dental Materials and Prosthodontics, School of DentistryOya TagitInstitute of Chemistry and Bioanalytics, School of Life SciencesJeroen J.J.P. van den BeuckenDentistry - Regenerative Biomaterials, Radboudumc, Philips Van Leydenlaan 25, Nijmegen 6525 GA, The NetherlandsAbhijna DasInstitute of Chemistry and Bioanalytics, School of Life SciencesCleyton Alexandre BiffeBrazilian Center for Research in Energy and Materials (CNPEM)Valentim Adelino Ricardo BarãoDepartment of Prosthodontics and PeriodontologyStéfany Barbosa Alves da CruzDepartment of Basic Sciences, School of DentistryEdilson ErvolinoDepartment of Basic Sciences, School of DentistryLeonardo Perez FaveraniDepartment of Oral Diagnosis, Division of Oral and Maxillofacial Surgery, Piracicaba Dental SchoolVinícius Franzão GanzaroliDepartment of Basic Sciences, School of DentistryDaniela Leal Zandim-BarcelosDepartment of Diagnostic and Surgery, School of DentistryMagda FeresDepartment of Oral Medicine, Infection, and ImmunityBelén Retamal‐ValdesDepartment of PeriodontologyDenise Madalena Palomari SpolidorioDepartment of Physiology and Pathology, School of DentistryAna Cláudia PavarinaDepartment of Dental Materials and Prosthodontics, School of DentistryAmanda Paino SantanaDepartment of Diagnosis and Surgery, School of DentistryBeatriz Severino VerzaDepartment of Dental Materials and Prosthodontics, School of DentistryRodrigo Fernando Costa MarquesDepartment of Analytical Chemistry, Physical Chemistry and Inorganic, Institute of ChemistryRafael Scaf de MolonDepartment of Diagnosis and Surgery, School of DentistryÉrica Dorigatti de ÁvilaDepartment of Dental Materials and Prosthodontics, School of Dentistry

ACS Applied Materials & Interfacesjournal2025en

ABI

Аннотация

A stimuli-responsive drug delivery coating is proposed for titanium (Ti) implants to locally treat infectious and peri-implant inflammatory diseases. The system integrates a pH-responsive film based on poly(methacrylic acid) (PMAA) film over a layer-by-layer (LbL) drug delivery platform containing tetracycline (TC) complexed with anionic beta cyclodextrin (βCD). This smart coating was designed to control drug release, maintain antimicrobial activity against biofilm-forming pathogens, and enhance soft tissue sealing at the implant interface. The coating effectively regulated drug release, exhibited favorable hydrophilicity, and reduced surface roughness compared with untreated Ti surfaces. Cytocompatibility was confirmed in both monolayer cell cultures and collagen matrix environments, with no cytotoxic effects observed up to 6 days. Atomic force microscopy (AFM) revealed enhanced interactions between the PMAA film and cellular components, as evidenced by filopodial projections at the cell margins. The coating’s antibacterial properties were validated using human saliva-derived biofilms, demonstrating broad-spectrum antimicrobial activity against pathogens typically involved in dental implant infections. In vivo, a rat subcutaneous tissue model was used to evaluate the immune response. The LbL/TCβCD/PMAA coating significantly reduced inflammation, increased collagen deposition, and elevated CD206 expression, indicating a shift toward an anti-inflammatory and tissue-repair phenotype. This stimuli-responsive coating represents a promising strategy for localized infection control, drug delivery, and soft tissue integration on implant surfaces.

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Темы

Bone Tissue Engineering Materials Polymer Surface Interaction Studies Dental Implant Techniques and Outcomes

Идентификаторы

DOI: 10.1021/acsami.5c19344

Цитирования и источники

Цитирований: 0Использованных источников: 66

Показатели — AkademScholar · Скоро