Статья

Human selection maintains karyotype integrity of highly unstable genomic cultivated autotetraploid potato ( <i>Solanum tuberosum</i> )

Lu YangCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaYanbo BaiCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaGetu ChaoCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaKanglu ZhaoCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaJunxiong XuCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaManchao SunCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaHong ZhangCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaYaqingqing NiuCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaKexin LiCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaZinan XiongCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaYao CaoCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaFei WangCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaHai BaoCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaChun-Mei CaoInner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot, Inner Mongolia 010070, ChinaYuhe YinInstitute of Ulanqab Agricultural and Forestry Sciences, Inner Mongolia 012000, ChinaTuanrong LinInstitute of Ulanqab Agricultural and Forestry Sciences, Inner Mongolia 012000, ChinaYufeng WangInstitute of Ulanqab Agricultural and Forestry Sciences, Inner Mongolia 012000, ChinaXiufeng GongCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaLei WuCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, ChinaJiming JiangDepartment of Horticulture, Michigan State University, East Lansing, MI 48824, USAZhiyong XiongCollege of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, China

Science Advancesjournal2025en

ABI

Аннотация

), the third most important food crop globally, is represented by cultivated potato, an autotetraploid with highly heterozygous genomes. Here, we revealed that cultivated potato showed different chromosomal pairing configurations and irregular chromosomal segregations, resulting in a high proportion of aneuploid gametes. Aneuploidy was identified in inbreeding and outbreeding populations of cultivated potato, with frequencies ranging from 14.8 to 24.0%, indicating notable genomic instability. Extensive novel copy number variations (CNVs) were detected in the progeny, which may increase genetic diversity. Molecular karyotyping of 50 commercial varieties revealed that all varieties were euploid, with significantly fewer CNVs, indicating that human selection maintains karyotypic integrity. Aneuploids in the outbreeding population exhibited poor agronomic traits and fitness defects, which demonstrated that genomic instability increases phenotypic diversity. Our study provides insights into genetic basis and phenotypic plasticity of cultivated potato, offering guidance for future breeding strategies.

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Темы

Chromosomal and Genetic Variations Plant Pathogens and Resistance Genomic variations and chromosomal abnormalities

Идентификаторы

DOI: 10.1126/sciadv.aea5207

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