Assessment of endothelial function in overweight pregnant women with hypertension using levels of nitric oxide and flow-mediated vasodilatation test
Аннотация
Abstract Objective To assess endothelial dysfunction in overweight pregnant women with pre-existing hypertension. Methods Study included 55 pregnant women of 2 groups. First group (n=34) of healthy pregnant women. Second group (n=24) of women with pre-existing hypertension. Endothelial function was also analyzed using flow-mediated dilation (FMD) test and level of nitric oxide (NO) concentration. NO level were assessed by P.P. Golikov method. Statistical processing was carried out using the Statistica 13.0 program. P < 0.05 was considered statistically significant. Results There was no significant difference in age (27 in 1 group vs 29 in 2 group, P = 0.0658) and number of pregnancies (3.3 in 1 group vs 3.2 in 2 group, P = 0.7920). Mean level of blood pressure in group hypertension was: systolic blood pressure (SBP) of 153.83 mmHg. vs 102.72 mmHg in group 1 (P <0.0001), diastolic blood pressure (DBP) 96.16mmHg. vs 64.77 mmHg. in 1st group (P <0.0001). 23 women (95.8%) with hypertension were overweight, of which 15(62.5%) with obesity of I and II degree. In healthy group only 7 women (16%) were overweight, and no obese women. Mean value of FMD for 1 group was 6.2% vs 4.82 (P <0.0001), meanwhile NO was 8.8 mmol/l in group 1 vs NO 13.7 mmol\l (P <0.0001). Conclusion In conclusion, FMD measured by using an ultrasound system and determination of the blood serum NO level is associated with early diastolic dysfunction in overweight pregnant women with CHT.