VARIABILITY OF ARTERIAL BLOOD PRESSURE AND INTIMA-MEDIA THICKNESS COMPLEX AND THEIR GENOTYPES IN ARTERIAL HYPERTENSION PATIENTS IN THE UZBEK POPULATION.

Objective: To investigate the relationship between arterial blood pressure variability, intima-media complex (IMC) thickness, and specific genotypes in patients from the Uzbek population diagnosed with arterial hypertension complicated by atrial fibrillation. The study aims to identify potential genetic and physiological markers that influence IMC thickening and arterial pressure variability, which may contribute to a better understanding of the pathogenesis of these conditions and inform personalized treatment strategies. Design and method: This study analyzed 200 Uzbek patients with AH complicated by AF, dividing them into high and low IMC thickness groups based on a 1.0 mm threshold (M = 1.0, SD = 0.2). Blood pressure variability was monitored using 24-hour ambulatory methods, IMC thickness was measured via ultrasound, and genetic analysis of rs6817105 and rs11773845 genotypes was conducted using PCR. Statistical tests identified significant associations (p < 0.05) between IMC thickness, blood pressure variability, and genetic markers. Results: Patients with high IMC thickness had significantly greater nocturnal blood pressure variability compared to those with low IMC thickness. The mean nocturnal systolic and diastolic variabilities in the high IMC group were 14.36 ± 2.1 mmHg and 12.73 ± 1.8 mmHg, respectively, versus 11.88 ± 1.5 mmHg and 9.46 ± 1.3 mmHg in the low IMC group (p < 0.05). Daytime variability showed no significant difference between groups. Genetic analysis revealed that the rs6817105 (CT) genotype was more frequent in the high IMC group (25%) compared to the low IMC group (20%), while the rs6817105 (TT) genotype was more common in the low IMC group (15%) than the high IMC group (8%). The rs11773845 (AC) allele was slightly more frequent in the high IMC group (24%) than in the low IMC group (27%). All observed differences were statistically significant (p < 0.05). Conclusions: Increased IMC thickness is significantly associated with enhanced nocturnal blood pressure variability and may serve as a marker of unfavorable cardiovascular outcomes in patients with AH complicated by AF. Genotypes rs6817105 (CT) and rs11773845 (AC) were associated with greater IMC thickness and blood pressure variability, suggesting their involvement in the pathogenesis of these conditions.

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