Angiomyomatous hamartoma masquerading as lymphoproliferative disease in a teenager

Angiomyomatous hamartoma of lymph nodes (AMH-LN) is an uncommon benign proliferation of smooth muscle, blood vessels, collagenous stroma, and adipocytes, most commonly affecting inguinal lymph nodes (LN).[1] We present a diagnostic journey of a 16-year-old male who initially came with bilateral inguinal lymphadenopathy. Histological evaluation suggested a diagnosis of non-Hodgkin lymphoma, while immunohistochemical analysis indicated findings consistent with “Castleman disease.” However, further comprehensive imaging, repeated histopathological examinations, and immunohistochemical studies ultimately revealed the unexpected diagnosis of angiomyomatous hamartoma (AMH) of the lymph nodes. The case underlines the necessity of multidisciplinary approaches to avoid misdiagnosis and unnecessary interventions in pediatric and adolescent patients presenting with lymphadenopathy. This rare and benign condition turned into a diagnostic challenge, highlighting the importance of careful histological evaluation in ruling out malignancies.

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