Epidemiological Features of Escherichia сoli Strains’ Susceptibility Monitoring
Аннотация
Urinary tract infection (UTI) is a common infection seen in both community and hospital settings. Antibiotic treatment is essential for achieving a favorable outcome of UTI. However, the increasing prevalence of antibiotic-resistant bacteria in urine has made it difficult to select appropriate antibacterial therapy. The aim of the study was the analysis of antibiotic susceptibility of Escherichia coli in UTIs. Material and methods. The study was conducted using biological material (urine) collected from patients in different hospital departments, which was received in the bacteriological laboratory of the Republican Scientific and Practical Medical Center of Urology (P6), for the period from January 2020 to December 2022. Nutrient media and discs with antimicrobial drugs manufactured by Himedia (India) were used. Results. Analyzing the data of positive results of bacteriological studies, it was revealed that the dominant pathogen is Escherichia coli , which accounted for 70% of all isolated pathogens; Klebsiella pneumoniae was isolated in 9% of cases, and Pseudomonas aeruginosa — in 6%. The conducted analysis of the resistance of E. coli strains isolated from patients in the hospital showed a high level of resistance to antimicrobial drugs. The highest resistance rates were observed toward ampicillin, ceftazidime, cefepime, norfloxacin, ciprofloxacin, levofloxacin, and moxifloxacin. The studyrevealed that uropathogenic E. coli strains had high resistance to beta-lactam antimicrobial drugs, including inhibitor-protected ones, and the range of resistance varied from 23.1 to 77.8%, depending on the type of antimicrobial drug and the year of isolation of E. coli strains.