Synthesis of Heteropolymetallophosphate Ionophores and Development of Ion-Selective Electrodes for Rapid Detection of Pharmaceuticals

The optimal conditions for obtaining poorly soluble electrode-active substances based on molybdenum- and tungsten-containing heteropolycompounds (HPCs) and pharmaceutical drugs were selected. The composition and structure of the obtained electrode-active compounds were determined using IR spectroscopy, scanning electron microscopy, X-ray diffraction, and X-ray fluorescence analysis. During the research, ion-selective electrodes (ISEs) for pharmaceutical drug detection based on HPCs were developed, and their electroanalytical characteristics were studied. A total of 24 types of ion-selective membranes were synthesized using dodecamolybdophosphate (DDMP) and dodecatungstophosphate (DDTP) ionophores, polyvinyl chloride (PVC), and dioctyl phthalate. It was proven that DDMP-based membranes exhibit high sensitivity (10⁻⁵–10⁻⁶ mol/L) to dibazole and pyridoxine, while DDTP-based membranes show the same level of sensitivity to diprazine and bromhexine.

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