#1428 Laboratory markers of nephrolithiasis

Abstract Background Urolithiasis (urolithiasis (NL)) is a widespread pathology throughout the world, occurring on all continents and climatic zones, in every race and nationality, in every country with any level of economic development. About 2% of the world's population have experienced the symptoms of this pathology at least once, often at the age of 20–30 years, a widespread disease throughout the world. The incidence of NL fluctuates between 0.5–5.5% annually, and in certain endemic areas for this pathology - within 13–20%. Aims To study the most common indicators of general and biochemical blood tests, as well as coagulograms in children with urolithiasis. Method Children under 7 years of age with a diagnosis of urolithiasis with damage to the left kidney - 22 children, the right - 18 children, both - 17 children were examined. The gender ratio of the patients studied was 1.1:1 in favor of boys. A control group (CG) of 30 practically healthy patients was formed. Results There were 1.3 times more children with left kidney LD than children with right and both kidneys, their number was almost identical. In 75.44% of patients' stones, the average concentration of whewellite was 42.79 ± 2.25% and this was the highest concentration of oxalate salts in the group, weddellite was found in 84.21% with an average concentration of 39.67 ± 2.34%, thus, oxalates prevailed in our study in children. Reliable laboratory markers of nephrolithiasis were: mean corpuscular hemoglobin concentration (337.5 g/dl, P < 0.01), platelet distribution width (11.9 ± 0.4%, P < 0.001), large platelet coefficient (17.5 ± 0.8%, P < 0.001), hypomagnesemia, hypernatremia, and increased thrombin time (32.7 ± 1.2 sec, P < 0.001). According to the composition of stones, biurate/ammonium hydrourates (46.7%), wevelites (42.8%), wedelites (39.7%), and triglyceride (16.7%) were most often recorded. Conclusion Thus, the reliable differences we obtained in the above indicators between the studied groups of patients allow us to recommend them as markers for early diagnosis of the risk of developing urolithiasis in children.

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