#1429 Features of lithogenic and anti-lithogenic factors in urine in stone formation in children

Abstract Background Urolithiasis (UCD) is a chronic disease characterized by the formation of stones in the urinary system (urolithiasis, nephrolithiasis) from salts and organic compounds of the urine, occurring against the background of metabolic disorders in the body and / or urinary system. Since the disease recurs, every effort should be made to identify the underlying metabolic disorder that caused it and provide adequate treatment. Aims In order to maximize coverage of possible markers of nephrolithiasis in children, we also analyzed the relative indicators of biochemical urine analysis - the ratio of minerals to creatinine in urine. Method In this study, we examined urine tests of 60 patients with urolithiasis, as part of the metabolic examination, the following was assessed: the content of calcium, phosphorus, magnesium, oxalates, uric acid citrate, creatinine clearance, as well as determining the ratio of trace elements and creatinine. All patients were divided into groups by age and gender. Results We recorded a statistically significant increase in the excretion of Na and K in urine in patients with ICD 158.79 ± 8.95 mmol/l and 74.95 ± 3.15 mmol/l, respectively, while the indicators of the control group (CG) were 127.18 ± 4.11 and 49.88 ± 2.98 mmol/l, respectively (P ≤ 0.001). The level of oxalate excretion in the main group increased by 2.5 times relative to the CG, while citrates and Mg++ excretion in urine significantly decreased by 1.9 times and 2 times (P ≤ 0.001). A significant difference with the control group in the level of uric acid was noted (P ≤ 0.05). Assessment of the metabolic risk of exposure to lithogenic factors for the development of nephrolithiasis in children has established high diagnostic reliability for the following indicators: Ca++/Cr (0.706–0.863 U), Mg++/Cr (0.312–0.193 U), P+/Cr (3.978–5.577 U), Cl−/Cr (29.278–30.583 U), Na+/Cr (17.909–19.771 U), K+/Cr (6.756–8.588 U), Oxalates/Cr (0.060–0.075 U), Citrates/Cr (0.111–0.097 U), MK/Cr (0.371–0.435 U). Conclusion These criteria can be used to predict metabolic disorders in children with a high risk of stone formation.

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