CARDIAC HYPERTROPHY AT THE CELLULAR LEVEL: LITERATURE REVIEW
Mustafoev, Zafar MustafoevichAssociate Professor of the Department of Human Anatomy, Samarkand State Medical UniversityAbduxamidov, Firdavs Arslon oʻgʻliStudent of the Faculty of General Medicine, Samarkand State Medical UniversityAbdurazzoqova, Marjona Rustamjon qiziStudent of the Faculty of General Medicine, Samarkand State Medical UniversityNasriddinova, Xulkaroy BobomurodovnaStudent of the Faculty of General Medicine, Samarkand State Medical University
Zenodo (CERN European Organization for Nuclear Research)repository2025
ABI
Аннотация
Cardiac hypertrophy (CH) is an adaptive increase in myocardial mass that initially serves to normalize wall stress and preserve cardiac output in response to chronic hemodynamic overload. However, persistent stimulation transforms this compensatory process into pathological remodeling, characterized by cardiomyocyte dysfunction, fibrosis, and eventual heart failure. This comprehensive review explores CH at the cellular and molecular levels, emphasizing distinctions between physiological and pathological hypertrophy, as well as the microstructural, metabolic, and signaling alterations underlying disease progression.
Перевод пока недоступен
Темы
Идентификаторы
Цитирования и источники
Цитирований: 0Использованных источников: 0