Morphological Characteristics of the Kidneys in Laboratory Animals after Acute Irradiation with Preventive Biocorrection

This study investigates histomorphological changes in the kidneys of laboratory albino rats exposed to acute radiation and evaluates the protective effects of preventive biocorrection. Histological examination showed that in 30% of cases the renal histoarchitectonics remained unchanged, while in 36.7% the renal capsule exhibited uniform thickness and in 70% the glomeruli preserved their normal morphology. In animals that received preventive biocorrection, the frequency of pathological alterations-such as hydropic degeneration of the tubular epithelium, glomerular deformation, and vascular congestion-was significantly reduced compared with irradiated rats that did not undergo biocorrection. Furthermore, reparative regeneration processes in glomerular podocytes and tubular epithelial cells were observed only in the biocorrected group (23.3%). These findings demonstrate that preventive biocorrection helps maintain renal structural integrity, reduces radiation-induced damage, and activates reparative regenerative mechanisms. Thus, the proposed preventive biocorrection method is biologically safe, clinically effective, and economically feasible, offering promising potential for mitigating radiation-induced renal injury.

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