EFFECTS OF FERULA TADSHIKORUM RESIN EXTRACT ON CELL VOLUME REGULATION IN RAT THYMOCYTES AND MEMBRANE INTEGRITY OF HUMAN ERYTHROCYTES
Fayziev, DiyorInstitute of Biophysics and biochemistry at the National university of UzbekistanKurbannazarova, RanokhonInstitute of Biophysics and biochemistry at the National university of UzbekistanSabirov, RavshanInstitute of Biophysics and biochemistry at the National university of Uzbekistan
Zenodo (CERN European Organization for Nuclear Research)repository2025
ABI
Аннотация
The study presents data on the ethanol extract of Ferula tadshikorum resin. It was found that the extract inhibits the cell volume regulation system in thymocyte cells and induces the formation of pores with a radius of ~3.3 nm in the erythrocyte membrane. The extract decreases the resistance of cells to osmotic and colloid-osmotic stress, with lytic effects occurring at concentrations <10 μg/mL, while sublytic effects are observed even at 1 μg/mL.
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