Electrochemical Determination of Carboplatin

The article presents a method for determining carboplatin using amperometric titration in a Britton–Robinson universal buffer solution (pH 1.81–9.0) in the presence of thioacetamide. Based on the research results, it was shown that this method has high sensitivity and reproducibility. The equivalence point was determined by amperometric titration. This method is convenient and suitable for quantifying carboplatin in the biochemical analysis of oncology patients undergoing chemotherapy, as well as in pharmaceutical analysis.

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