Study OF Homocysteine Levels in Women with Congenital Defects AND A History OF Non-Progression

Reducing maternal and infant morbidity and mortality remains a major medical and social priority, with the prevention of pregnancy complications and fetal malformations representing a key strategy for achieving this goal. Disturbances in folate metabolism and elevated homocysteine levels are recognized risk factors for adverse pregnancy outcomes, including congenital malformations and early reproductive losses. This study aimed to assess homocysteine levels in women with a history of congenital fetal malformations and nonviable pregnancies and to evaluate the effectiveness of L-methylfolate and vitamin B12 supplementation. A total of 155 women with complicated obstetric and perinatal histories were included in the study. Patients in the main groups received L-methylfolate at a dose of 800 μg/day and vitamin B12 (cyanocobalamin) at a dose of 18 μg/day from the preconception period through pregnancy. Homocysteine levels were measured before treatment and dynamically during therapy.

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