Обзорная статья

Dual role of miR-155 and exosomal miR-155 in tumor angiogenesis: implications for cancer progression and therapy

Qusay Mohammed HussainAlsalam University CollegeAli Fawzi Al-HussainyCollege of Pharmacy, Ahl Al Bayt University, Kerbala, IraqGaurav SanghviMarwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot, Gujarat, 360003, IndiaR. RoopashreeDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, IndiaAditya KashyapCentre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, 140401, IndiaDaniel Alex AnandDepartment of Biomedical, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, IndiaRajashree PanigrahiDepartment of Microbiology, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, IndiaNargiz ShavaziDepartment of Obstetrics and Gynecology, Samarkand State Medical University, Samarkand, UzbekistanSada Ghalib TaherCollege of Dentistry, University of Thi-Qar, Thi-Qar, 64001, IraqMariem AlwanPharmacy College, Al-Farahidi University, Baghdad, IraqMahmood Jasem JawadDepartment of Pharmacy, Al-Zahrawi University College, Karbala, IraqHiba Mushtaq

European journal of medical researchjournal2025en

ABI

Аннотация

Tumor angiogenesis facilitates cancer progression by supporting tumor growth and metastasis. MicroRNA-155 (miR-155) plays a pivotal role in regulating angiogenesis through both direct effects on tumor and endothelial cells and indirect modulation via exosomal communication. This review highlights miR-155's pro-angiogenic influence on endothelial cell behavior and tumor microenvironment remodeling. Additionally, exosomal miR-155 enhances intercellular communication, promoting vascularization in several cancers. Emerging therapeutic strategies include miR-155 inhibition using antagomirs, exosome-mediated delivery systems, and modulation of pathways such as JAK2/STAT3 and TGF-β/SMAD2. Targeting miR-155 represents a promising approach to hinder tumor angiogenesis and improve cancer therapy outcomes.

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Темы

Extracellular vesicles in disease MicroRNA in disease regulation Circular RNAs in diseases

Идентификаторы

DOI: 10.1186/s40001-025-02618-z

Цитирования и источники

Цитирований: 1 Использованных источников: 137

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