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Gadolinium (Gd)-based nanostructures as dual-armoured materials for microbial therapy and cancer theranostics

Nadhir N.A. JafarAL-Zahraa University for Women, College of Health and Medical TechnologyJunainah Abd HamidManagement and Science UniversityFarag M. A. AltalbawyDepartment of Chemistry, University College of Duba, University of TabukPawan SharmaDepartment of Chemistry, School of Sciences, Jain (Deemed-to-be) UniversityAbhishek KumarDepartment of Pharmacy, Arka Jain UniversityShirin ShomurotovaDepartment of Chemistry Teaching Methods, Tashkent State Pedagogical University Named After NizamiRafid Jihad AlbadrPharmacy College, Ahl al Bayt UniversityKamil K. Atiyah AltameemiFaculty of Pharmacy/Department of Pharmaceutics, University of Al-AmeedHawraa Mahdi SalehFakhri AlajeeliDepartment of Medical Laboratories Technology, Al-Hadi University CollegeAhmed AhmedDepartment of Medical Laboratories Technology, Al-Nisour University College, Nisour Seq. KarkhIrfan AhmadCentral Labs, King Khalid UniversityImad Ibrahim DawoodDepartment of Medical Laboratories Technology, Mazaya University College
ABI

Аннотация

Gadolinium (Gd) nanoparticles hold significant promise in medical theranostics due to their unique properties. This review outlines the synthesis, characterisation, and applications of Gd nanostructures in combating microbial threats and advancing cancer theragnostic strategies. Synthesis methods such as co-precipitation, microemulsion, and laser ablation are discussed, alongside TEM, SEM, and magnetic characterisation. The antimicrobial efficacy of Gd nanostructures, their potential in combination therapy, and promising anticancer mechanisms are explored. Biocompatibility, toxicity, and regulatory considerations are also evaluated. Challenges, future perspectives, and emerging trends in Gd nanostructure research are highlighted, emphasising their transformative potential in medical applications.

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