Обзорная статья

Natural Metabolites as Modulators of Sensing and Signaling Mechanisms: Unlocking Anti-Ovarian Cancer Potential

Megha VermaSchool of Medical & Allied Sciences, Galgotias University, Greater Noida 201310, Uttar Pradesh, IndiaPrem Shankar MishraFaculty of Pharmacy, Vidya University, Meerut 250002, Uttar Pradesh, IndiaSk. Abdul RahamanSchool of Medical & Allied Sciences, Galgotias University, Greater Noida 201310, Uttar Pradesh, IndiaTanya GuptaSchool of Medical & Allied Sciences, Galgotias University, Greater Noida 201310, Uttar Pradesh, IndiaAbid Ali SheikhNational Institute of Biologicals, Noida 201309, Uttar Pradesh, IndiaAshok Kumar SahDepartment of Medical Laboratory Sciences, College of Applied and Health Sciences, A’ Sharqiyah University, Ibra 400, OmanVelilyaeva Aliya SabrievnaDepartment of Psychiatry, Medical Psychology, and Narcology, Samarkand State Medical University, Samarkand 140104, UzbekistanKaromatov Inomdzhon DzhuraevichDepartment of Folk Medicine and Professional Diseases, Bukhara State Medical Institute, Bukhara 200101, UzbekistanAnass M. AbbasDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72341, Saudi ArabiaManar G. ShalabiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72341, Saudi ArabiaMuhayyoxon KhamdamovaBukhara State Medical Institute (Abu Ali Ibn Sina), Bukhara 200118, UzbekistanBaymuradov Ravshan RadjabovichDepartment of Anatomy, Clinical Anatomy (OSTA), Bukhara State Medical Institute, Bukhara 140100, UzbekistanF. G. KarimovaDepartment of Traditional Medicine, Occupational Diseases and Allergology, Abu Ali ibn Sino Bukhara State Medical Institute, Bukhara 140100, UzbekistanRanjay Kumar ChoudharyDepartment of Medical Laboratory Technology, UIAHS, Chandigarh University, Mohali 140413, Punjab, IndiaSaid Al GhenaimiDepartment of Medical Laboratory Sciences, College of Applied and Health Sciences, A’ Sharqiyah University, Ibra 400, Oman

Biomedicinesjournal2025en

ABI

Аннотация

Cancer presents significant challenges owing to its complex molecular pathways and resistance to therapy. Natural metabolites have significant medicinal potential by regulating the sensing and signaling pathways associated with cancer development. Recognizing their interactions within the tumor microenvironment may unveil innovative techniques for inhibiting malignant activities and improve therapy success. This article highlights studies regarding ovarian cancer metabolism, signaling mechanisms, and therapeutic natural substances. This study summarizes clinical and experimental results to emphasise the synergistic effects of alkaloids, flavonoids, and terpenoids in improving therapeutic effectiveness and alleviating drug resistance. Bioactive compounds are essential in regulating ovarian cancer metabolism and signaling pathways, affecting glycolysis, lipid metabolism, and the survival of tumor cells. This review examines metabolic programming and essential pathways, including glycolysis, TCA cycle, lipid metabolism, PI3K/AKT/mTOR, AMPK, and MAPK, emphasizing their therapeutic significance. The integration of metabolic treatments with medicines based on natural compounds has significant potential for enhancing treatment effectiveness and mitigating therapeutic resistance. Ovarian cancer needs an integrated strategy that includes metabolic reprogramming, signaling modulation, and drugs derived from natural products. Natural chemicals provide intriguing approaches to address chemotherapy resistance and improve treatment efficacy. Further research is required to enhance these methodologies and evaluate their practical applicability for improved patient outcomes.

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Темы

Cancer, Lipids, and Metabolism Cancer, Hypoxia, and Metabolism Cancer Mechanisms and Therapy

Идентификаторы

DOI: 10.3390/biomedicines13081830

Цитирования и источники

Цитирований: 0Использованных источников: 229

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