Development of a resorbable cava clip for the prevention of pulmonary artery thromboembolism in iliocaval thrombosis: an experimental study

Abstract. Objective of the study: development of a biocompatible, absorbable cava clip for the prevention of pulmonary embolism (PE) in patients with thrombosis of the iliocaval segment, which not only creates a barrier to thromboemboli while maintaining blood flow, but also undergoes resorption within a predetermined timeframe once the risk of PE has passed. Materials and methods. The production of the designed «Absorbable cava clips» was carried out through preliminary 3D modeling, followed by 3D printing. The experimental study was conducted in the Department of Experimental Surgery at the Republican Research Center of Emergency Medicine. The study included the following laboratory animals: 49 rats (25 white Vistar rats and 24 outbred rats), 6 outbred mice, and 3 guinea pigs. The purpose of the experiment was to perform a morphological study of the caudal vein and surrounding tissues after implantation of the absorbable clip, to determine the resorption period, and to evaluate toxicological safety indicators. Results. As a result of the study, a model of an «absorbable cava clip» made of PGLA was developed, which meets the requirements of toxicological safety. Morphological studies demonstrated signs of clip degradation on day 30 of the experiment, with complete resorption observed by day 60. Comparison of microscopic changes identified in the five experimental groups clearly demonstrated the course of a typical inflammatory process in the surrounding tissues and vessel wall, replacement of the inflammatory zone with connective tissue, and the absence of mural thrombosis or structural changes of the endothelium.

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