Acute Toxicity and Antitoxic Effect of Compositions of Cytisine N-Alkyl (Aryl) Derivatives with Succinic Acid
Latipova Shaxla BekdurdiyevnaAssistant of the Department of Pharmacology and Clinical Pharmacology, Urgench state medical university, Urgench, UzbekistanAzamatov Azizbek Azamat o‘g‘liPhD, Senior researcher at the Department of Pharmacology and Toxicology of the Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanTursunkhodzhaeva Firuza MuratovnaDSc, professor, Head of the Department of Pharmacology and Toxicology of the Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanAytmuratova Urkhiya KallibekovnaPhD student, Department of Pharmacology and Toxicology, the Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
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Аннотация
In the article, the acute toxicity, resorptive effects, and antitoxic activity of N-alkyl (aryl) derivatives of cytisine and their compositions with succinic acid were studied in experimental animals using models of alcohol- and hypnotic-induced intoxication. The results demonstrated that these compositions possess relatively low acute toxicity and exhibit antitoxic effects under conditions of narcotic intoxication by reducing the duration of sleep.
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