ETIOLOGICAL FACTORS AND PATHOGENETIC MECHANISMS OF ANEMIA IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION

This study provides a comprehensive clinical and statistical analysis of the etiological factors contributing to anemia in 84 patients diagnosed with Chronic Hepatitis C (CHC) at the Andijan State Medical Institute clinic. Utilizing a combination of retrospective and prospective methodologies, the research identifies a significant anemia prevalence of 32.1% among the cohort. Systematic evaluation reveals that the pathogenesis of this hematological complication is multifactorial: ribavirin-induced hemolysis was the primary driver in 44% of cases, followed by chronic systemic inflammation (33%), and hypersplenism associated with portal hypertension (23%). Statistical comparison demonstrated a critical reduction in mean hemoglobin levels within the anemic group (94.2 ± 3.8 g/L) relative to the control group (132.5 ± 5.1 g/L), validated by Student’s t-test and $\chi^2$ analysis ($p < 0.05$). The findings conclude that anemia in CHC is not a solitary occurrence but rather a synergistic result of pharmacotherapeutic adverse effects and the virus-induced inflammatory response. These results underscore the necessity for personalized monitoring of hematological parameters to optimize treatment outcomes in CHC patients.

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