The role of C28078G <i>PPAR</i> gene polymorphism in the occurrence and clinical course of acne in Uzbek population
Аннотация
Background. Acne (acne vulgaris) is a multifactorial chronic inflammatory skin disease of the sebaceous glands and hair follicles. Nearly 80% of first-degree relatives suffer from acne, and the condition tends to occur earlier and be more severe in those with a family history. There is now sufficient evidence to suggest that various series of candidate genes, which protein products are directly or indirectly involved in the regulation of the immune response during inflammation, play a role in the predisposition to acne. Despite this, the molecular and genetic basis of acne has not been sufficiently studied yet. Scientific studies have shown that PPAR receptors play a significant role in regulating inflammatory processes and in stimulating sebum production. Aim. To investigate the influence of the PPARγ (PPARG) gene in Uzbek patients suffering from acne of various severity. Methods. A case-control study was carried out on genomic DNA samples isolated from the patients’ peripheral blood. A total of 133 patients with acne of various severity were examined. The control group consisted of 125 apparently healthy Uzbek individuals with no dermatological or other medical disorders. Results. The frequency of the C and G alleles in the subgroup of patients with severe acne and in the control group was 81.6 and 18.4% vs 87.6 and 12.4%, respectively. The probability of detecting the unfavorable G allele in patients with severe acne was more than 2-fold higher than in the control group (a trend toward an increase; P = 0.1; OR = 2.2; 95% CI: 0.96–4.98). This suggests that the presence of the unfavorable G allele may be associated with an increased risk of severe acne. Conclusion. The 28078CG polymorphism in the PPARG gene plays a significant role in acne pathogenesis in Uzbek patients.