Comparative Clinical and Immunological Characteristics of Seripositive And Seronegative Rheumathoid Arthritis

To study and compare the diversity and specific characteristics of the clinical course of seronegative and seropositive Rheum factor, anti-CCP positive, and anti-CCP negative variants of rheumatoid arthritis. Methods: Information was collected from studies measuring visual analog scale (VAS) pain, disease activity score 28 (DAS28), X-ray of joints, tender joint count (TJC), swollen joint count (SJC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP). Results: The study included 80 patients with rheumatoid arthritis divided into two equal groups: seropositive and seronegative RA. The mean age was comparable between groups (36.87± years in Group I vs. 37.65± years in Group II), with a clear predominance of female patients in both groups (80% and 90%, respectively). Articular involvement was the most common clinical form; however, systemic (articular-visceral) manifestations were more frequent in the seronegative group (47.5% vs. 35%). Anti-CCP positivity was significantly higher in the seronegative group (67%) compared to the seropositive group (27%). Disease activity analysis revealed that moderate activity predominated in the seropositive group (55%), whereas high disease activity was more common in the seronegative group (57.5%). Regarding disease staging, the established (advanced) stage was the most frequent in both groups (55% in Group I and 60% in Group II), while very early stages were rare or absent.

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