Preclinical Evaluation of 5T4-Targeted [ <sup>89</sup> Zr]Zr-DFO-HB5 Immuno-PET Imaging and Comparison of <sup>161</sup> Tb vs <sup>177</sup> Lu Radionuclide Therapy for Colorectal Cancer
Yuanyuan LiangNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of MedicineXiangyun LiNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of MedicineHui LiangNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of MedicineTao WuNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of MedicineYao HuangNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of MedicineShoumei LiuNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of MedicineXia YangChina Academy of Engineering PhysicsRui LuoDepartment of Nuclear Medicine, Mianyang Central Hospital, School of MedicineFanxin MaSound Biopharmaceuticals Co., Ltd., Tianfu International Bio-Town, Huigu Dong Second Road 8, Chengdu, Sichuan 610200, ChinaYing HuangNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of MedicineXiaoan LiNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of MedicineYan ZhouNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine
ABI
Аннотация
Tb]Tb-DOTA-HB5 exhibits potent antitumor efficacy and favorable biosafety. The study provides a potential theranostic platform for 5T4-positive CRC and related malignancies.
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