Hyaluronic acid-based nanofibrous scaffolds incorporating <i>Nigella sativa</i> methanolic extract with multifunctional antimicrobial, antioxidant, anti-inflammatory, and anticancer properties for advanced wound healing
Hadil FarisDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint AbdulRahman University, Riyadh 11671, Saudi ArabiaFadhil Faez SeadDepartment of Dentistry, College of Dentistry, The Islamic University, Najaf, IraqFarag M. A. AltalbawyDepartment of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi ArabiaNawfal Y. JamilHealth and Medical Techniques College, Alnoor University, Nineveh, IraqAhmed Salih SahibCollege of Pharmacy, Ahl Al Bayt University, Kerbala, IraqUmida TashkenbaevaDepartment of Dermatovenerology and Cosmetology N1, Tashkent State Medical University, Tashkent, UzbekistanZahraa Saad AbdulaliCollege of Health and Medical Technology, National University of Science and Technology, Dhi Qar, 64001, IraqMariem AlwanPharmacy College, Al-Farahidi University, Baghdad, IraqMahmood JawadDepartment of Pharmacy, Al-Zahrawi University, Karbala, IraqHiba MushtaqAseel SmeratDepartment of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, IndiaSamar El-Tayeb IzzatDepartment of Pharmaceutical Chemistry, University of Khartoum, Khartoum, Sudan
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Аннотация
HA/NSME nanofibers: hyaluronic acid nanofibers loaded with Nigella sativa extract show antimicrobial (MIC: 1–4 µg mL −1 ), antioxidant (IC50: 8 µg mL −1 ), and anti-inflammatory (82% NO inhibition) activities for enhanced wound healing.
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