Статья

Synthesis and characterization of a novel nanomagnetic solid carboxylic acid for sustainable synthesis of pyrano[2,3-c]pyrazoles in water

Normurot FayzullaevDepartment of Polymer Chemistry and Chemical Technology, Samarkand State University, 140101, Samarkand, UzbekistanTeeba Ammar RashidMedical Laboratory Techniques Department, College of Health and Medical Techniques, University of Al-Maarif, Anbar, Iraq. [email protected]Safia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi ArabiaHamad AlMohamadiDepartment of Chemical Engineering, Faculty of Engineering, Islamic University of Madinah, Madinah, Saudi Arabia. [email protected]Yashwantsinh JadejaDepartment of Chemistry, Faculty of Science, Marwadi University Research Center, Marwadi University, Rajkot, Gujarat, 360003, IndiaAnirudh GuptaNIMS School of Allied Sciences and Technology, NIMS University, Rajasthan, Jaipur, 303121, IndiaAanchal SharmaDepartment of Medical Lab Sciences, Chandigarh Group of Colleges-Jhanjeri, Mohali, Punjab, 140307, IndiaG. V. Siva PrasadDepartment of Basic Sciences and Humanities, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, 531162, IndiaZahraa Khdair AbbasCollege of Pharmacy, The Islamic University, Najaf, IraqWesam R. KadhumDepartment of Pharmaceutics, College of Pharmacy, University of Kut, Al-Kut, 52001, Wasit, Iraq

Scientific Reportsjournal2026en

ABI

Аннотация

nanoparticles using an alkyl halide-based sialylation agent, followed by grafting with hexamine and subsequent reaction with chloroacetic acid. The resulting nanocomposite was thoroughly characterized using various structural, morphological, and physicochemical techniques to confirm its composition and architecture. The catalyst was then employed in the one-pot synthesis of pyrano[2,3-c]pyrazole derivatives via a multicomponent reaction of hydrazine hydrate, ethyl acetoacetate, and malononitrile with various substituted aryl aldehydes. The reactions proceeded efficiently in water as a green solvent, affording the desired products in good to excellent yields within short reaction times. The products were isolated by simple recrystallization without the need for chromatographic purification. Notably, the catalyst exhibited excellent reusability, being easily recovered using an external magnet and reused for up to six cycles with minimal loss of catalytic performance.

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Темы

Multicomponent Synthesis of Heterocycles Synthesis and biological activity Synthesis of Organic Compounds

Идентификаторы

DOI: 10.1038/s41598-026-49404-3

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