EVALUATION AND TREATMENT OF CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHOOBSTRUCTIVE SYNDROME IN EARLY CHILDREN

At present, all over the world, the study of the phenotypes of bronchial obstruction in children of early and preschool age remains a subject of great scientific interest. The identification of phenotypes is necessary for a better understanding of the etiopathophysiological, including epigenetic, mechanisms of the disease, the determination of predictors and the prediction of the risk of BA. In this regard, the aim of the study was to study the clinical and immunological features of broncho-obstructive syndrome in children of early and preschool age. On the basis of the SF of RSCEMA, 111 patients aged from 6 months to 3 years examined. The results of the study showed that under conditions of prolonged antigenic load, humoral immunity is activated; children with RSMS have hyperimmunoglobulinemia G and M, which is the cause of incomplete immunity. The initiation of activity through IL-6 of the macrophage link of the immune system as a nonspecific protective factor leads to an increase in oxygen-dependent killing mechanisms and reserve capacities of phagocytes in the early stages of the disease, followed by a decrease in the reserve capacities of phagocytes as a result of im-paired adaptive capabilities.

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