THE EFFECT OF MATERNAL DIABETES ON NEURODEGENERATIVE CHANGES IN THE SPINAL CORD AND VERTEBRAL COLUMN OF OFFSPRING

The morphological characterization of the vertebral column in offspring born under conditions of experimental diabetes has become a highly relevant topic in modern neuroendocrinology and fetal development research. This study investigated the effects of streptozotocin (STZ)- and alloxan-induced maternal diabetes on the structure of the spinal cord and vertebral column during both fetal and postnatal development. The results demonstrated that offspring of diabetic mothers exhibited a 15–30% reduction in spinal cord volume, a 45–65% decrease in neuronal density, alterations in dendritic spine numbers, increased glial activity, and epigenetic changes, including oxidative stress and dysregulation of gene expression. These findings indicate that maternal diabetes has a significant impact on the neurodevelopment of offspring and may contribute to long-term neurodegenerative alterations in the spinal cord and vertebral structures.

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