Surface‐Dominated and Translationally Relevant: Mxene Quantum Dots for Infection Control–Adaptive Wound Healing Systems

ABSTRACT MXene quantum dots (MQDs) are zero‐dimensional, surface‐dominated nanomaterials whose quantum confinement and chemically diverse terminations enable unusual interfacial activity in complex biological environments. This review provides the first focused and integrative assessment of MQDs within infection control–adaptive wound healing systems, emphasizing how physicochemical identity governs biological relevance and translational potential. Rather than cataloging applications, the discussion examines dimensional confinement, surface termination heterogeneity, colloidal dynamics, redox responsiveness, and physicochemical stability in physiological milieus, establishing a materials‐centered foundation for interpreting bio–nano interactions. Experimental evidence is evaluated to elucidate how surface‐dominated properties manifest in infection‐relevant microenvironments, including wound‐associated interfaces and structurally complex biological matrices. Particular attention is given to the distinction between intrinsic physicochemical responsiveness and context‐dependent biological outcomes, avoiding performance‐driven generalizations. Translational considerations—spanning safety profiles, physicochemical reproducibility, scalability, and regulatory alignment—are systematically analyzed to identify design principles required for clinical relevance. By unifying materials chemistry, interfacial science, and translational constraints, this review advances a conceptual framework in which MQDs are positioned as adaptive enablers of next‐generation wound healing strategies centered on infection control rather than single‐function efficacy.

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