Morphometric and Functional Predictors of Structural Changes in Kidneys in Less-Mobile Patients with Hypothyroidism

This study investigates the correlation between thyroid hormone deficiency and renal structural alterations in patients with limited physical activity. Hypothyroidism leads to decreased renal plasma flow, cardiac output, and GFR, which are significantly exacerbated by a sedentary lifestyle. We analyzed morphometric data (kidney volume, cortical thickness, tubular diameter) and functional markers (eGFR, creatinine) to identify early predictors of chronic kidney disease (CKD). Results indicate that reduced mobility significantly accelerates tubular atrophy and glomerular basement membrane thickening in hypothyroid states. Clinical evidence shows a higher prevalence of subclinical hypothyroidism (17.9%) in patients with GFR <60 ml/min. Thyroid hormone replacement therapy (THRT) remains a crucial intervention for the potential reversibility of these structural and functional impairments.

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