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Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

Gregory A. RothUniversity of Washington, Seattle, Washington, USA. Electronic address: [email protected]George A. MensahNational Heart, Lung, and Blood Institute (NHLBI), Bethesda, Maryland, USA. Electronic address: [email protected]Catherine O. JohnsonUniversity of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, USAGiovanni AddoloratoCatholic University of Rome, Rome, ItalyEnrico AmmiratiDe Gasperis Cardio Center and Transplant Center, Niguarda Hospital, Milan, ItalyLarry M. BaddourMayo Clinic, Rochester, Minnesota, USANoël C. BarengoHerbert Wertheim College of Medicine, Florida International University, Miami, Florida, USAAndrea BeatonCincinnati Children's Hospital, Cincinnati, Ohio, USAEmelia J. BenjaminBoston University School of Public Health, Boston, Massachusetts, USACatherine P. BenzigerEssentia Health, Duluth, Minnesota, USAAimé BonnyDistrict Hospital of Bonassama-University of Douala, Douala, CameroonMichael BräuerUniversity of British Columbia, Vancouver, British Columbia, CanadaMarianne BrodmannMedical University of Graz, Graz, AustriaThomas J. CahillJonathan R. CarapetisTelethon Kids Institute, Nedlands, Western Australia, AustraliaAlberico L. CatapanoUniversity of Milano, Milan, ItalySumeet S. ChughCedars-Sinai, Smidt Heart Institute, Los Angeles, California, USALeslie T. CooperMayo Clinic, Jacksonville, Florida, USAJosef CoreshJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USAMichael H CriquiUniversity of California at San Diego, San Diego, California, USANicole DeCleeneThe University of Michigan Samuel and Jean Frankel Cardiovascular Center, Ann Arbor, Michigan, USAKim A. EagleThe University of Michigan Samuel and Jean Frankel Cardiovascular Center, Ann Arbor, Michigan, USASophia Emmons‐BellUniversity of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, USAValery L. FeiginUniversity of Washington, Seattle, Washington, USAJoaquim Fernández‐SolàBarnaclinic+ Grup Hospital Clinic, Barcelona, SpainGerry FowkesUniversity of Edinburgh, Edinburgh, United KingdomEmmanuela GakidouUniversity of Washington, Seattle, Washington, USAScott M. GrundyUniversity of Texas Southwestern Medical Center, Dallas, Texas, USAFeng J. HeQueen Mary University of London, London, United KingdomGeorge HowardUniversity of Alabama at Birmingham School of Public Health, Birmingham, Alabama, USAFrank B. HuHarvard Medical School, Boston, Massachusetts, USALesley A. InkerTufts Medical Center, Boston, Massachusetts, USAGanesan KarthikeyanCardiothoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, IndiaNicholas J KassebaumUniversity of Washington, Seattle, Washington, USAWalter J. KoroshetzNational Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USACarl J. LavieOchsner Health, New Orleans, Louisiana, USADonald M. Lloyd‐JonesNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USAHong LüUniversity of Kentucky College of Medicine, Lexington, Kentucky, USAAntonio MirijelloIRCCS Casa Sollievo della Sofferenza Hospital, Department of Medical Sciences, San Giovanni Rotondo, ItalyAwoke Misganaw TemesgenUniversity of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, USAAli H. MokdadUniversity of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, USAAndrew MoranColumbia University Irving Medical Center, New York, New York, USAPaul MuntnerUniversity of Alabama at Birmingham School of Public Health, Birmingham, Alabama, USAJagat NarulaIcahn School of Medicine at Mount Sinai, New York, New York, USABruce NealThe University of Sydney School of Medicine, Sydney, New South Wales, AustraliaMpiko NtsekheUniversity of Cape Town, Cape Town, South AfricaGlaucia Moraes de OliveiraUniversidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilCatherine M OttoUniversity of Washington, Seattle, Washington, USAMayowa OwolabiUniversity of Ibadan, Ibadan, Oyo State, NigeriaMichael PrattUniversity of California at San Diego, San Diego, California, USASanjay RajagopalanCase Western Reserve University School of Medicine, Cleveland, Ohio, USAMarissa B ReitsmaStanford University School of Medicine, Stanford, California, USAAntônio Luiz Pinho RibeiroUniversidade Federal de Minas Gerais, Minas Gerais, BrazilNancy A. RigottiMassachusetts General Hospital, Boston, Massachusetts, USAAnthony RodgersThe George Institute for Global Health, Newtown, New South Wales, Australia; Imperial College of London, London, United KingdomCraig SableChildren's National Hospital, Washington, DC, USASaate ShakilUniversity of Washington, Seattle, Washington, USAKaren Sliwa‐HahnleUniversity of Cape Town, Cape Town, South AfricaBenjamin StarkUniversity of Washington, Seattle, Washington, USAJohan SundströmUppsala University, Uppsala, SwedenPatrick TimpelDresden University of Technology, Dresden, GermanyImad M. TleyjehKing Fahd Medical City, Riyadh, Saudi ArabiaMarco ValgimigliInselspital, University Hospital Bern, Bern, SwitzerlandTheo VosUniversity of Washington, Seattle, Washington, USAPaul K. WheltonTulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USAMagdi YacoubImperial College of London, London, United KingdomLiesl ZühlkeUniversity of Cape Town, Cape Town, South AfricaChris MurrayUniversity of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, USAValentı́n FusterIcahn School of Medicine at Mount Sinai, New York, New York, USA; Centro Nacional de Investigaciones Cardiovasculares, Madrid, SpainCatherine O. JohnsonUniversity of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, USAMichael H CriquiUniversity of California at San Diego, San Diego, California, USANicole DeCleeneThe University of Michigan Samuel and Jean Frankel Cardiovascular Center, Ann Arbor, Michigan, USAKim A. EagleThe University of Michigan Samuel and Jean Frankel Cardiovascular Center, Ann Arbor, Michigan, USAF. Gerry R. FowkesUniversity of Edinburgh, Edinburgh, United Kingdom;
ABI

Аннотация

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases.

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