An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia
Morten RasmussenCentre for GeoGenetics, Natural History Museum of Denmark, and Department of Biology, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkXiaosen GuoShenzhen Key Laboratory of Transomics Biotechnologies, BGI-Shenzhen, Shenzhen 518083, ChinaYong WangDepartments of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA 94720, USAKirk E. LohmuellerDepartments of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA 94720, USASimon RasmussenCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, DenmarkAnders AlbrechtsenDepartment of Biology, University of Copenhagen, 2200 Copenhagen, DenmarkLine SkotteDepartment of Biology, University of Copenhagen, 2200 Copenhagen, DenmarkStinus LindgreenCentre for GeoGenetics, Natural History Museum of Denmark, and Department of Biology, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkMait MetspaluDepartment of Evolutionary Biology, Tartu University and Estonian Biocentre, 23 Riia Street, 510101 Tartu, EstoniaThibaut JombartMRC Centre for Outbreak, Analysis and Modeling, Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, London W2 1PG, UKToomas KivisildLeverhulme Centre for Human Evolutionary Studies, Department of Biological Anthropology, University of Cambridge, Cambridge CB2 1QH, UKWeiwei ZhaiBeijing Institute of Genomics, Chinese Academy of Sciences, No. 7 Beitucheng West Road, Chaoyang District, Beijing 100029, ChinaAnders ErikssonEvolutionary Ecology Group, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UKAndrea ManicaEvolutionary Ecology Group, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UKLudovic OrlandoCentre for GeoGenetics, Natural History Museum of Denmark, and Department of Biology, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkFrancisco M. De La VegaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USASilvana R. TridicoAncient DNA Lab, School of Biological Sciences and Biotechnology, Murdoch University, Western Australia 6150, AustraliaEne MetspaluDepartment of Evolutionary Biology, Tartu University and Estonian Biocentre, 23 Riia Street, 510101 Tartu, EstoniaKasper NielsenCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, DenmarkMaría C. Ávila‐ArcosCentre for GeoGenetics, Natural History Museum of Denmark, and Department of Biology, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkJ. Víctor Moreno-MayarCentre for GeoGenetics, Natural History Museum of Denmark, and Department of Biology, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkCraig MullerGoldfields Land and Sea Council Aboriginal Corporation, 14 Throssell Street, Kalgoorlie, Western Australia 6430, AustraliaJoe DortchArchaeology, University of Western Australia, Crawley, Western Australia 6009, AustraliaM. Thomas P. GilbertCentre for GeoGenetics, Natural History Museum of Denmark, and Department of Biology, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkOle LundCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, DenmarkAgata WesolowskaCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, DenmarkMonika KarminDepartment of Evolutionary Biology, Tartu University and Estonian Biocentre, 23 Riia Street, 510101 Tartu, EstoniaLucy A. WeinertMRC Centre for Outbreak, Analysis and Modeling, Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, London W2 1PG, UKBo WangShenzhen Key Laboratory of Transomics Biotechnologies, BGI-Shenzhen, Shenzhen 518083, ChinaJun LiShenzhen Key Laboratory of Transomics Biotechnologies, BGI-Shenzhen, Shenzhen 518083, ChinaShuaishuai TaiShenzhen Key Laboratory of Transomics Biotechnologies, BGI-Shenzhen, Shenzhen 518083, ChinaFei XiaoShenzhen Key Laboratory of Transomics Biotechnologies, BGI-Shenzhen, Shenzhen 518083, ChinaTsunehiko HaniharaDepartment of Anatomy, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, JapanGeorge van DriemInstitut für Sprachwissenschaft, Universität Bern, 3000 Bern 9, SwitzerlandAashish R. JhaDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USAFrançois‐Xavier RicautLaboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, Université de Toulouse (Paul Sabatier)–CNRS UMR 5288, 31073 Toulouse Cedex 3, FrancePeter de KnijffDepartment of Human and Clinical Genetics, Postzone S5-P, Leiden University Medical Center, 2333 ZA Leiden, NetherlandsAndrea Bamberg MiglianoDepartment of Anthropology, University College London, London WC1E 6BT, UKIrene Gallego RomeroDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USAKarsten KristiansenDepartment of Biology, University of Copenhagen, 2200 Copenhagen, DenmarkDavid M. LambertGriffith School of Environment and School of Biomolecular and Physical Sciences, Griffith University, Nathan, Queensland 4111, AustraliaSøren BrunakCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, DenmarkPeter ForsterMurray Edwards College, University of Cambridge, Cambridge CB3 0DF, UKBernd BrinkmannInstitute for Forensic Genetics, D-48161 Münster, GermanyOlaf NehlichDepartment of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, GermanyMichael BunceAncient DNA Lab, School of Biological Sciences and Biotechnology, Murdoch University, Western Australia 6150, AustraliaMichael P. RichardsDepartment of Anthropology, University of British Columbia, Vancouver, British Columbia V6T 1Z1, CanadaRamneek GuptaCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, DenmarkCarlos D. BustamanteDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USAAnders KroghCentre for GeoGenetics, Natural History Museum of Denmark, and Department of Biology, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkRobert A. FoleyLeverhulme Centre for Human Evolutionary Studies, Department of Biological Anthropology, University of Cambridge, Cambridge CB2 1QH, UKMarta Mìrazón LahrLeverhulme Centre for Human Evolutionary Studies, Department of Biological Anthropology, University of Cambridge, Cambridge CB2 1QH, UKFrançois BallouxMRC Centre for Outbreak, Analysis and Modeling, Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, London W2 1PG, UKThomas Sicheritz‐PonténCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, DenmarkRichard VillemsDepartment of Evolutionary Biology, Tartu University and Estonian Biocentre, 23 Riia Street, 510101 Tartu, EstoniaRasmus NielsenDepartment of Biology, University of Copenhagen, 2200 Copenhagen, DenmarkJun WangDepartment of Biology, University of Copenhagen, 2200 Copenhagen, DenmarkEske WillerslevCentre for GeoGenetics, Natural History Museum of Denmark, and Department of Biology, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark
2011en
ABI
Аннотация
We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.
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