Статья

Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy

Reiko NishiharaDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USAKana WuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical SchoolPaul LochheadDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthTeppei MorikawaDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthXiaoyun LiaoDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthZhi Rong QianDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthKentaro InamuraDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthSun A. KimDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthAya KuchibaDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthMai YamauchiDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthYu ImamuraDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthWalter C. WillettChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical SchoolBernard RosnerBiostatistics, Harvard School of Public HealthCharles S. FuchsChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical SchoolEdward L. GiovannucciChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical SchoolShuji OginoDepartment of Medical Oncology, Dana–Farber Cancer Institute and Harvard Medical School, Harvard School of Public HealthAndrew T. ChanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School

2013en

ABI

Аннотация

BACKGROUND: Colonoscopy and sigmoidoscopy provide protection against colorectal cancer, but the magnitude and duration of protection, particularly against cancer of the proximal colon, remain uncertain. METHODS: We examined the association of the use of lower endoscopy (updated biennially from 1988 through 2008) with colorectal-cancer incidence (through June 2010) and colorectal-cancer mortality (through June 2012) among participants in the Nurses' Health Study and the Health Professionals Follow-up Study. RESULTS: Among 88,902 participants followed over a period of 22 years, we documented 1815 incident colorectal cancers and 474 deaths from colorectal cancer. With endoscopy as compared with no endoscopy, multivariate hazard ratios for colorectal cancer were 0.57 (95% confidence interval [CI], 0.45 to 0.72) after polypectomy, 0.60 (95% CI, 0.53 to 0.68) after negative sigmoidoscopy, and 0.44 (95% CI, 0.38 to 0.52) after negative colonoscopy. Negative colonoscopy was associated with a reduced incidence of proximal colon cancer (multivariate hazard ratio, 0.73; 95% CI, 0.57 to 0.92). Multivariate hazard ratios for death from colorectal cancer were 0.59 (95% CI, 0.45 to 0.76) after screening sigmoidoscopy and 0.32 (95% CI, 0.24 to 0.45) after screening colonoscopy. Reduced mortality from proximal colon cancer was observed after screening colonoscopy (multivariate hazard ratio, 0.47; 95% CI, 0.29 to 0.76) but not after sigmoidoscopy. As compared with colorectal cancers diagnosed in patients more than 5 years after colonoscopy or without any prior endoscopy, those diagnosed in patients within 5 years after colonoscopy were more likely to be characterized by the CpG island methylator phenotype (CIMP) (multivariate odds ratio, 2.19; 95% CI, 1.14 to 4.21) and microsatellite instability (multivariate odds ratio, 2.10; 95% CI, 1.10 to 4.02). CONCLUSIONS: Colonoscopy and sigmoidoscopy were associated with a reduced incidence of cancer of the distal colorectum; colonoscopy was also associated with a modest reduction in the incidence of proximal colon cancer. Screening colonoscopy and sigmoidoscopy were associated with reduced colorectal-cancer mortality; only colonoscopy was associated with reduced mortality from proximal colon cancer. Colorectal cancer diagnosed within 5 years after colonoscopy was more likely than cancer diagnosed after that period or without prior endoscopy to have CIMP and microsatellite instability. (Funded by the National Institutes of Health and others.).

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Идентификаторы

DOI: 10.1056/nejmoa1301969

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Цитирований: 2Использованных источников: 0

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