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Graphene quantum dots in biomedical applications: Recent advances and future challenges

Fei ChenChongqing Medical University, Fifth Clinical College of Chongqing Medical University, Chongqing 400016, ChinaWeiyin GaoDepartment of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, ChinaXiaopei QiuBioengineering College of Chongqing University, Chongqing 400044, ChinaHong ZhangDepartment of Clinical and Military Laboratory Medicine, School of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing 400038, ChinaLianhua LiuBioengineering College of Chongqing University, Chongqing 400044, ChinaPu LiaoClinical Laboratory Center of Chongqing, Chongqing 400014, ChinaWeiling FuSouthwest HospitalYang LuoDepartment of Clinical and Military Laboratory Medicine, School of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
2017en
ABI

Аннотация

Graphene quantum dots (GQDs)-based nanohybrid materials have gained great attention in multiple research applications, particularly in biomedical fields due to their unique physicochemical properties and outstanding biocompatibility compared to other nanomaterials. In this review, we focus on the most recent emerging developments including synthesis methods, in vivo imaging and in vitro biosensing applications. We also discuss these unresolved problematic and controversial issues facing their biomedical applications. Consequently, trends in approaches to improve the analytical performance of GQDs-based nanomaterials have also been put forward. Keywords: Graphene quantum dots (GQDs), Immunosensors, Imaging, Drug delivery, Toxicity

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