Обзорная статья

Global Prevalence and Major Risk Factors of Diabetic Retinopathy

Joanne YauCentre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, AustraliaSophie RogersCentre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, AustraliaRyo KawasakiCentre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, AustraliaEcosse L. LamoureuxCentre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, AustraliaJonathan W. KowalskiGlobal Health Outcomes Strategy and Research, Allergan Inc., Irvine, CaliforniaToke BekDepartment of Ophthalmology, Aarhus University Hospital, Aarhus, DenmarkShih‐Jen ChenDepartment of Ophthalmology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, TaiwanJoost DekkerDepartment of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the NetherlandsAstrid FletcherDepartment of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, U.KJakob GrauslundDepartment of Ophthalmology, Odense University Hospital, Odense, DenmarkSteven M. HaffnerRichard F. HammanDepartment of Epidemiology, Colorado School of Public Health, Aurora, ColoradoM. Kamran IkramDepartments of Epidemiology and Ophthalmology, Erasmus Medical Center, Rotterdam, the NetherlandsTakamasa KayamaNational Cancer Center/Department of Neurosurgery, Advanced Molecular Epidemiology Research Institute, Faculty of Medicine, Yamagata University, Yamagata, JapanBarbara E.K. KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WisconsinRonald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WisconsinSannapaneni KrishnaiahCenter for Clinical Epidemiology and Biostatistics, L V Prasad Eye Institute, Hyderabad, IndiaKorapat MayurasakornDepartment of Social Medicine, Samutsakhon General Hospital, Samutsakhon, ThailandJoseph Paul O’HareClinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, U.KTrevor J. OrchardDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PennsylvaniaMassimo PortaDepartment of Internal Medicine, University of Turin, Turin, ItalyM. RemaDepartment of Ophthalmology, Madras Diabetes Research Foundation, Chennai, IndiaMonique RoyTarun SharmaShri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, IndiaJonathan E. ShawBaker IDI Heart and Diabetes Institute, Melbourne, Victoria, AustraliaHugh R. TaylorMelbourne School of Population Health, University of Melbourne, Melbourne, Victoria, AustraliaJames M. TielschDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandRohit VarmaDoheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CaliforniaJie Jin WangCentre for Vision Research, Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, AustraliaNingli WangBeijing Tongren Hospital, Capital Medical University, Beijing, ChinaSheila K. WestWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MarylandLiang XuBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaMiho YasudaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanXinzhi ZhangDivision of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GeorgiaPaul MitchellCentre for Vision Research, Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, AustraliaTien Yin WongCentre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australiafor the Meta-Analysis for Eye Disease (META-EYE) Study Group

2012en

ABI

Аннотация

OBJECTIVE: To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN AND METHODS: A pooled analysis using individual participant data from population-based studies around the world was performed. A systematic literature review was conducted to identify all population-based studies in general populations or individuals with diabetes who had ascertained DR from retinal photographs. Studies provided data for DR end points, including any DR, proliferative DR, diabetic macular edema, and VTDR, and also major systemic risk factors. Pooled prevalence estimates were directly age-standardized to the 2010 World Diabetes Population aged 20-79 years. RESULTS: A total of 35 studies (1980-2008) provided data from 22,896 individuals with diabetes. The overall prevalence was 34.6% (95% CI 34.5-34.8) for any DR, 6.96% (6.87-7.04) for proliferative DR, 6.81% (6.74-6.89) for diabetic macular edema, and 10.2% (10.1-10.3) for VTDR. All DR prevalence end points increased with diabetes duration, hemoglobin A(1c), and blood pressure levels and were higher in people with type 1 compared with type 2 diabetes. CONCLUSIONS: There are approximately 93 million people with DR, 17 million with proliferative DR, 21 million with diabetic macular edema, and 28 million with VTDR worldwide. Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR. These data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence. This study is limited by data pooled from studies at different time points, with different methodologies and population characteristics.

Перевод пока недоступен

Идентификаторы

DOI: 10.2337/dc11-1909

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar